This text is oriented toward planning police operations in the public sector, but will be usable by other public officials as well as some private sector police operations. It addresses police threat assessment of, vulnerability assessment to, defense against and response to attacks by special weapons of mass destruction in a civilian setting. These include chemical, biological and radiological attacks. It begins with a review of the policy and legal issues pertaining to special weapons and of the pertinent counter-terrorist response considerations discussed in the author¹s other book, POLICE ANALYSIS AND PLANNING FOR VEHICULAR BOMBINGS. It continues with assessment of the various types of special weapons of mass destruction and the terrorist¹s ability to make and use them, a historical review of significant incidents for each of the major subcategories of weapons, the limitations of police response operations in the United States, and defense response to this form of attack. It concludes with commentary on actions that may be needed if this threat continues to develop in the United States. Hopefully, this text will be of benefit to those officers and officials that have never had to confront this type of problem, and will help build the skill and psychological preparation for battle that prevents the attack and enables effective response.